PharmaTimes: The University of Oxford has launched a Phase I trial of a novel mosaic vaccine targeting a ‘broad range’ of HIV variants.
The HIV-CORE 0052 trial, part of the European Aids Vaccine Initiative, will involve 13 healthy HIV-negative adults aged 18 to 65 years old who are not considered to be at a high risk of infection.
The participants will receive one dose of the vaccine – known as the HIVconsvX vaccine – followed by a further boost dose at four weeks.
HIVconsvX, unlike other HIV vaccine candidates which are designed to induce antibodies generated by B-cells, is designed to induce the immune system’s T cells and targeting them to highly conserved and vulnerable regions of HIV. more