Simulations conducted by Oracle supercomputing revealed COVID-19 to be “highly adapted” for human infection, discrediting the claim of the virus counting natural origins through a spillover event from wildlife to humans.
Very quickly, he had a result – and it was a result that caused him a great deal of angst. “Strangely, humans came out at the very top of the list.” Petrovsky pauses. “That was not what we were expecting, as the animal host from which the virus had been transmitted should have been at the top of the list. This presented a puzzle as the data suggested the SARS-CoV-2 spike protein had uniquely evolved to bind and infect cells expressing human ACE2. Normally with a new pandemic virus, whatever species that virus originally came from would be the best fit and the virus would initially only half fit the human lock but then mutate over time to try and become a better fit. A virus should not be able to evolve to be a perfect fit for a lock it has never seen, and yet this is what the data was telling us. The virus spike protein looked like it couldn’t have been better designed to fit the human ACE2. Go figure.”
“Notably, SARS-CoV-2 spike protein had the highest overall binding energy for human ACE2, greater than all the other tested species including bat, the postulated source of the virus. This indicates that SARS-CoV-2 is a highly adapted human pathogen,” noted the paper.